Predictive potential of macrophage population phenotyping in malignization of H. pylori-associated chronic gastritis

Tumor-associated macrophages are able to regulate the tumor cell proliferation and affect dissemination. The study was aimed assess predictive potential of macrophage population immunohistochemical phenotyping in early malignization H. pylori-associated chronic gastritis. Gastic biopsy samples male female patients aged 48 ± 7.2 infected with Helicobacter pylori were used as research material. divided into three groups: non-atrophic gastritis (NACG, n = 10), atrophic (ACG, G1/G2 gastric adenocarcinoma (GAC, 10). visualized using CD68 pan-macrophage marker type 2 monocyte/macrophage CD163. Intensity neoangiogenesis defined CD31 endothelial by assessing total cross sectional area blood vessels. It found that accompanied dynamic increase size general progression metaplastic processes. According biopsies obtained from NCG, CD163 : ratio 0.67 0.02, vessels 3590.92 356.27 µm2. Atrophic characterized vector redistribution monocytes/macrophages 2nd functional phenotype. expression index group ACG 0.81 0.04, GAC it 0.88 0.03. Microvascular significantly increased groups GAC, which reflected intensification under influence М2 monocytes/macrophages. can serve a predictor together evaluation glandular epithelium atrophy metaplasia degree.